Specific Treatment for Congenital Syphilis
Based on Section 3.3.2b, Subsection 3.2, Section III of the Guidelines for Diagnosis and Treatment of Syphilis (Promulgated under Decision 5186/QD-BYT in 2021), the specific treatment regulations are as follows:
Congenital Syphilis
- Indications for treatment:
+ Congenital syphilis diagnosed definitively.
+ Newborns without clinical manifestations but born to mothers with untreated or inadequately treated syphilis, treated late (within 30 days before delivery), or treated with a regimen other than penicillin, not following the treatment guidelines for pregnant women in section 3.2.2.
- Treatment regimens: choose one of the following regimens
+ Benzyl penicillin 100,000 – 150,000 units/kg/day, administered intravenously slowly for 10-15 days
+ Procaine penicillin 50,000 units/kg/day, administered intramuscularly for 10-15 days.
Preference should be given to the benzyl penicillin regimen over the procaine penicillin regimen if intravenous administration is possible.
- Newborns without clinical manifestations and whose mothers have been adequately treated for syphilis, showing no signs of reinfection, only require close monitoring. The risk of mother-to-child transmission of syphilis depends on multiple factors, including the mother’s non-specific antibody test titers (e.g., RPR), the treatment duration, and the stage of the mother’s disease. If treatment is necessary, use the regimen:
Benzathine penicillin G 50,000 units/kg/day, administered intramuscularly, as a single dose.
Respectfully!
